Graft-versus-host disease (GVHD) remains a major cause of morbidity and mortality post-hematopoietic cell transplant (HCT). The pathophysiology of acute GVHD involves priming of immune response by pre ...

A researcher has made a discovery that alters our understanding of how the body's DNA repair process works and may lead to new chemotherapy treatments for cancer and other disorders. Researchers ...

Human cancers exhibit genomic instability and an increased mutation rate due to underlying defects in DNA repair. Cancer cells are often defective in one of six major DNA repair pathways, namely: ...

The ongoing fight of science against cancer has made great strides, but cancer cells have not made it easy. The complexity of cancer cells and their adaptive evolutionary nature complicate the search ...

ERCC1 mRNA expression and XRCC1 polymorphism as predictive factors for overall survival in gastric cancer patients receiving platinum based chemotherapy ...

OGG1 is a key enzyme in the base excision repair pathway, responsible for removing oxidized bases from DNA. In idiopathic pulmonary fibrosis (IPF), emerging evidence suggests that OGG1 also ...

DNA repair pathways exist to correct molecular damage caused by internal and external factors. However, any damage to these pathways can result in the creation of tumors and specific types of cancers.