Summary of topoisomerase types and catalytic mechanisms. The topoisomerases are categorized based on whether they catalyze single- (type I) or double-stranded (type II) DNA breaks.

Nov 25, 2023 · What is DNA Topoisomerase. How does it work. What do they do. Learn their types and structure with a diagram.

Feb 27, 2023 · What is Topoisomerase? Topoisomerase is an essential enzyme that aids in the DNA replication process, segregation of chromosomes, transcription, and also in recombination.

Bacteria also possess their own distinct types of topoisomerases, such as DNA gyrase, which is a Type II topoisomerase. Because these bacterial enzymes are structurally different from their …

Topoisomerase I is catalytically active as a 100-kDa monomer and is concentrated in nucleoli, although smaller amounts are found in a diffuse nuclear distribution. The gene for this enzyme …

Topoisomerase is a class of enzymes that play a crucial role in DNA metabolism and regulate the topological state of DNA.

Feb 28, 2022 · Ahmad, M. et al. Topoisomerase 3β is the major topoisomerase for mRNAs and linked to neurodevelopment and mental dysfunction. Nucleic Acids Res. 45, 2704–2713 (2017).

Topoisomerase is a type of enzyme that helps maintain the structural integrity of DNA during various cellular processes. DNA, by its very nature, tends to become supercoiled due to the …

The topoisomerase field continues to expand and blossom in new and unexpected ways and will continue to do so if researchers incorporate new approaches, ideas, and data into their analyses.

DNA topoisomerase VIII (topo VIII), discovered in 2014, is a novel member of the topo family. Identified through database screening using S. shibatae Top6B, topo VIII was classified as a …